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. 2019 Jun 6;20(2):1131–1138. doi: 10.3892/mmr.2019.10352

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Copyright: © Qi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Anti-IL-12 alleviates SS and decreases the percentage of MDSCs in BM and SP of NOD mice. Eleven-week-old NOD mice were intraperitoneally treated with (NOD+Anti-IL-12) or without (Ctrl) anti-IL-12. (A) Anti-IL-12 treatment schedule. (B) Lymphocytic infiltration in SGs from mice. Arrows indicate the locus of lymphocytic infiltration in SGs. (C) Salivary flow rate of mice. (D) Representative flow cytometry graphs of BM and SP MDSCs. (E) Summary of flow cytometry results of BM and SP MDSCs. Error bars indicate SEM. *P<0.05, n=5. IL-12, interleukin-12; SS, Sjögren's syndrome; MDSCs, myeloid-derived suppressor cells; SGs, submandibular glands; BM, bone marrow; SP, spleen.