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IL-12 deficiency impairs generation of MDSCs in C57BL/6 mice. (A) SP MDSCs were detected by flow cytometry in 8-week-old C57BL/6 (B6) and Il-12−/- B6 mice. (B) Kinetic changes of SP MDSCs at 4, 6, 8 and 10 weeks of age in the Il-12−/− B6 mice. Error bars indicate SEM. *P<0.05, n=5. W, week; IL-12, interleukin-12; MDSCs, myeloid-derived suppressor cells; SP, spleen.
