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. 2019 Jun 5;20(2):1321–1332. doi: 10.3892/mmr.2019.10345

Figure 9.

Figure 9.

Effects of ART on the levels of key molecules involved in the TLR4-NF-κB signaling pathway in RAW264.7 cells. (A) Western blot analysis demonstrated the effects of ART on the levels of key molecules involved in TLR4-NF-κB signaling. (B) LPS treatment increased the protein expression levels of TLR4, p-NF-κB, p-p38, Bax and caspase-9, and downregulated Bcl-2, whereas exposure to ART reverses these effects. No significant differences in the expression levels of NF-κB and p38 were reported among all groups. ***P<0.001 vs. control group; #P<0.05 and ##P<0.01 vs. LPS group. ART, artesunate; LPS, lipopolysaccharide; 5-ASA, 5-aminosalicylic acid; TLR4, toll-like receptor 4; NF-κB, nuclear factor-κB; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein.