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. 2019 Jun 4;20(2):1093–1102. doi: 10.3892/mmr.2019.10330

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Copyright: © Yuan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effects of TβRI/II kinase inhibitor (LY2109761) on TGF-β₁/Smads pathway in CFs. CFs were cultured for 48 h at 37°C in an HG group (40 mM), R568 (5 µM), HG+Calhex231 (3 µM) and HG+R568+LY2109761 (20 µM) group. Representative western blots of TGF-β₁, TβRI, TβRII in comparison with β-actin expression and p-Smad2 in comparison with t-Smad2 expression in CFs are provided. **P<0.01, ***P<0.001, ****P<0.0001 vs. the Control; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. HG; ^@@P<0.01 vs. R568 (n≥3). HG, high glucose; p-/t-Smad, phosphorylated/total Smad; TGF, transforming growth factor; TβRI, TGF-β-type I receptor; CFs, cardiac fibroblasts.