Table 1.
Study population characteristics
| Patient number | Pregnancy number | Age of delivery (year) | Age of epilepsy onset (year) | Gestational age at birth (week) | Dose used prior to pregnancy (mg) | Target concentration (mg/L) | Birth weight of fetus (g) | Sex of fetus | Apgar score of fetus | Seizure types before pregnancy | Types and numbers of seizures in | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1st trimester | 2nda trimester | 3rd trimester | |||||||||||
| 1 | 1 | 41 | 8 | 39 | — | — | 3,100 | F | 10 | FIA | — | FIA1 | — |
| 2 | 2 | 30 | 16 | 38 | 150 | 2.73 | 3,300 | F | 10 | GTC, FIA | FIA1 | FIA3 | — |
| 3 | 3 | 27 | 16 | 38 | — | — | 3,600 | M | 10 | GTC, FIA | — | FIA2 | FIA3 |
| 4 | 4 | 22 | 14 | 38 | 100 | 2.72 | 3,400 | M | 10 | GTC, FIA | — | GTC3, FIA1 | — |
| 5 | 5 | 26 | 12 | 38 | 50 | 1.80 | 2,700 | F | 10 | GTC | — | — | — |
| 6 | 6 | 30 | 10 | 38 | — | — | 2,850 | F | 10 | GTC | — | — | — |
| 7 | 7 | 30 | 1 | 39 | 75 | 1.43 | 3,000 | M | 10 | GTC | — | GTC2 | — |
| 8 | 8 | 20 | 10 | 37 | 50 | 1.90 | 3,000 | F | 10 | GTC, FIA | — | FIA2 | — |
| 9 | 9 | 33 | 14 | 39 | 100 | 3.18 | 3,400 | F | 10 | GTC | — | — | — |
| 10 | 10 | 28 | 10 | 37 | — | — | 3,050 | M | 10 | GTC | — | — | — |
| 11 | 11 | 26 | 18 | 39 | — | — | 3,300 | F | 10 | GTC | — | — | — |
| 12 | 12 | 30 | 24 | 40 | 125 | 2.33 | 3,570 | M | 10 | GTC, FIA | — | GTC1 | GTC1 |
The number behind represents the number of seizure attacks.
Abbreviations: FIA, focal impaired awareness; GTC, generalized tonic–clonic seizure.
a
χ2 test for seizures between the first and the second trimesters (p = 0.0304), χ2 test for seizures between the second and the third trimester (p = 0.0917).