Figure 4:

Effect of intra-CeA injections of URB597 (1.0 μg/rat) in msP rats on: a) % time spent in open arms; b) % number of open arm entries, c) % number of closed arm entries, d) total arm entries. URB597 exerted an anxiolytic-like effect in rats subjected to restraint stress as indicated by a higher percentage of time spent in the open arms. The effect of URB597 on open and closed arm entries are consistent with evidence of increased time spent exploring the open arms. Data are represented as the mean ± SEM. ###p<0.001 statistical differences versus V-STR (vehicle, restrained animals); **p<0.01***p<0.001 statistical differences versus V-V (vehicle, non-restrained animals).