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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Cancer Res. 2019 Jan 18;79(6):1239–1251. doi: 10.1158/0008-5472.CAN-18-2725

Fig. 4. Characterization of intracranial tumors derived from both WT and laminin-411 DKO U87MG cells by western blot.

Fig. 4.

Intracranial tumors were dissected from mice inoculated with either WT or the laminin-411 DKO U87MG cells. Tumor samples were collected from three animals per group at the endpoint of their survival and total lysates were used for western blotting analysis. Upper blot: Levels of laminin-411 α4 and β1 in U87MG tumors (WT vs. laminin-411 DKO. Compared to the WT U87MG tumors, the laminin-411 α4 and β1 levels remained significantly lower in DKO tumors; Lower blot: Levels of CSC markers in the tumor samples. Notch-1, Jagged1 as well as the CSC regulator c-Myc are significantly lower than in the WT tumors.