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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Immunol Allergy Clin North Am. 2019 May 15;39(3):335–344. doi: 10.1016/j.iac.2019.03.003

Figure 1: RV39 infection of Human Precision Cut Lung Slices (PCLS) from Asthma Donors.

Figure 1:

(A) Comparison of carbachol (CCh)-induced airway responsiveness in donors with and without asthma before and after infection with RV39. RV39 infection causes airway hyper-responsiveness to CCh only in PCLS from donors with a history of asthma. (B-E) IL25, TSLP, IL13, and IL-33 gene expression from RV39 infected PCLS. There are significant increases in the expression of IL-25, TSLP, and IL-13 in the PCLS from asthma donors compared to controls without asthma. (F, G) IL-33 and TSLP protein levels in supernatants from RV39 infected PCLS in donors with and without asthma. There are significantly increased TSLP protein levels in those donors with a history of asthma after infection with RV39.

* p<0.05

Adapted from Kennedy JL, Koziol-White CJ, Jeffus S, et al. Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices. J Allergy Clin Immunol 2018; 141(5): 1888; with permission.