Table 1.
Comparison of clinical and laboratory features between whole-cohort AML and non-APL AML patients with low and high expression.
| Patient parameters | Whole-cohort AML | Non-APL AML | ||||
|---|---|---|---|---|---|---|
| POU5F1Blow (n=145) | POU5F1Bhigh (n=30) | P value | POU5F1Blow (n=118) | POU5F1Bhigh (n=24) | P value | |
| Sex, Male/Female | 90/55 | 20/10 | 0.683 | 75/43 | 15/9 | 1.000 |
| Median age, years (range) | 57 (20–93) | 54 (21–83) | 0.105 | 61 (20–93) | 57 (28–83) | 0.135 |
| Median WBC, ×109/L (range) | 16.3 (0.4–528.0) | 5.5 (0.3–203.6) | 0.103 | 20.2 (0.4–528.0) | 4.6 (0.8–203.6) | 0.021 |
| Median hemoglobin, g/L (range) | 77.5 (32.0–144.0) | 77.0 (34.0–131.0) | 0.893 | 76.0 (32.0–144.0) | 77.5 (34.0–131.0) | 0.963 |
| Median platelets, ×109/L (range) | 40.0 (3.0–447.0) | 46.5 (4.0–415.0) | 0.937 | 42.0 (3.0–447.0) | 50.0 (4.0–415.0) | 0.714 |
| BM blasts,% (range) | 46.7 (3.0–99.0) | 37.5 (1.0–93.0) | 0.203 | 56.5 (10.5–99.0) | 43.0 (6.0–93.0) | 0.193 |
| CR (+/−) | 50/83 | 18/10 | 0.012 | 29/78 | 13/10 | 0.012 |
| FAB | 0.956 | 0.904 | ||||
| M0 | 2 | 1 | 2 | 1 | ||
| M1 | 10 | 1 | 10 | 1 | ||
| M2 | 56 | 13 | 56 | 13 | ||
| M3 | 27 | 6 | – | – | ||
| M4 | 29 | 5 | 29 | 5 | ||
| M5 | 16 | 3 | 17 | 3 | ||
| M6 | 5 | 1 | 5 | 1 | ||
| Karyotype classification | 0.353 | 0.329 | ||||
| Favorable | 37 | 8 | 12 | 2 | ||
| Intermediate | 78 | 20 | 77 | 20 | ||
| Poor | 21 | 1 | 21 | 1 | ||
| No data | 9 | 1 | 8 | 1 | ||
| Karyotype | 0.320 | 0.209 | ||||
| Normal | 57 | 18 | 56 | 18 | ||
| t(8;21) | 9 | 2 | 9 | 2 | ||
| t(15;17) | 25 | 6 | 0 | 0 | ||
| +8 | 6 | 0 | 6 | 0 | ||
| Others | 23 | 1 | 23 | 1 | ||
| Complex | 16 | 2 | 16 | 2 | ||
| No data | 9 | 1 | 8 | 1 | ||
| Gene mutation | ||||||
| CEBPA (+/−) | 14/106 | 3/23 | 1.000 | 14/85 | 3/18 | 1.000 |
| NPM1 (+/−) | 13/107 | 4/22 | 0.506 | 13/86 | 4/17 | 0.496 |
| FLT3-ITD (+/−) | 16/104 | 2/24 | 0.742 | 13/86 | 2/19 | 1.000 |
| c-KIT (+/−) | 6/114 | 1/25 | 1.000 | 5/94 | 1/20 | 1.000 |
| NRAS or KRAS (+/−) | 7/113 | 3/23 | 0.384 | 7/92 | 3/18 | 0.377 |
| IDH1/2 (+/−) | 6/114 | 1/25 | 1.000 | 6/93 | 1/20 | 1.000 |
| IDH2 R140(+/−) | 4/116 | 1/25 | 1.000 | 4/95 | 1/21 | 1.000 |
| DNMT3A (+/−) | 10/110 | 0/26 | 0.209 | 10/89 | 0/21 | 0.206 |
| U2AF1 (+/−) | 5/115 | 1/25 | 1.000 | 5/94 | 1/20 | 1.000 |
| SRSF2 (+/−) | 7/117 | 0/26 | 0.605 | 7/94 | 0/21 | 0.600 |