Table 3.

Mean SF-36 PF Scale Scores Pre- and Post-first vaccination^a by Day, Maximum Reactogenicity Grade, and Symptom Type (Total Vaccinated Cohort)

Day	Grade						Symptom Type
	0		1 or 2		3		None		Local		Systemic
	N	Mean Score	N	Mean Score	N	Mean Score	N	Mean Score	N	Mean Score	N	Mean Score
Pre-vaccination
−7	64	76.8	299	82.8	38	75.5	64	76.8	321	81.8	220	81.8
0	64	82.3	299	84.3	38	75.8	64	82.3	321	83.5	220	82.8
Post-first vaccination
1	61	84.8	299	84.1	38	65.2	64	84.8	321	82.0	220	79.7
2	62	84.7	299	85.5	38	68.0	61	84.7	321	83.8	220	82.3
3	62	84.9	298	85.7	38	74.8	62	84.9	320	84.5	220	83.7
4	62	84.8	298	85.6	38	75.7	62	84.8	320	84.5	220	83.6
5	62	85.0	298	85.7	38	77.2	62	85.0	320	84.8	220	84.0
6	62	85.0	298	85.7	38	74.7	62	85.0	320	84.5	220	83.7
7	45	83.1	220	85.4	21	75.5	45	83.1	227	84.7	156	82.9

Notes: N = total number of participants. High score represents high level of functioning/quality of life. Reactogenicity grading: 0 (none/normal); 1 (mild); 2 (moderate); 3 (severe; prevents normal activity); for swelling/redness: greatest surface diameter 0 (<20 mm); 1 (≥20 to ≤50 mm); 2 (>50 to ≤100 mm); 3 (>100 mm); for temperature: 0 (<37.5°C); 1 (37.5–38.0°C); 2 (38.1–39.0°C); 3 (>39.0°C). Participants characterized according to maximum reactogenicity grade or symptom type reported within 7 days post-first vaccination (none = participants with no solicited symptom reported; local = participants with at least one solicited local symptom reported; systemic = participants with at least one solicited general symptom reported; participants can be included in both local and systemic categories).

^aRecombinant zoster vaccine Dose 1 administered on Day 0.