Table 2.
Proportional Hazard Ratios and 95% Confidence Intervals of Estimated Effects of Tertiles of MIND, Mediterranean, and DASH diet Scores on Time to Incident Disability on Activities of Daily Living scale (n = 809) in Memory and Aging Project Participants Over a Mean 5.3 Years of Follow-up, 2004–2017
| Score Range | No. of Events/N | Model 1† | Model 2‡ | Model 3§ | |
|---|---|---|---|---|---|
| MIND Diet Score | |||||
| T1 | 3.0–7.0 | 175/293 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| T2 | 7.5–8.5 | 139/265 | 0.75 (0.60–0.95) | 0.78 (0.62–0.98) | 0.76 (0.60–0.96) |
| T3 | 9.0–13.0 | 124/251 | 0.67 (0.53–0.86) | 0.71 (0.56–0.91) | 0.65 (0.51–0.84) |
| p trend | .002 | .01 | .001 | ||
| Mediterranean Diet Score | |||||
| T1 | 18–30 | 179/316 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| T2 | 31–34 | 135/246 | 0.80 (0.63–1.01) | 0.84 (0.66–1.06) | 0.81 (0.63–1.03) |
| T3 | 35–46 | 124/247 | 0.73 (0.57–0.94) | 0.76 (0.59–0.97) | 0.73 (0.56–0.95) |
| p trend | .01 | .03 | .02 | ||
| DASH Diet Score | |||||
| T1 | 1.0–3.5 | 199/349 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| T2 | 4.0–4.5 | 129/219 | 0.92 (0.73–1.15) | 0.94 (0.75–1.19) | 0.94 (0.74–1.20) |
| T3 | 5.0–8.5 | 110/241 | 0.74 (0.58–0.95) | 0.76 (0.60–0.98) | 0.77 (0.60–0.98) |
| p trend | .02 | .04 | .05 | ||
Notes: Cox-Proportional hazard model was used. DASH = Dietary Approaches to Stop Hypertension; MIND = Mediterranean–DASH Diet Intervention for Neurodegenerative Delay; T1 = tertile 1; T2 = tertile 2; T3 = tertile 3.
†Model 1 adjusted for age, sex, education, smoking, physical activity, and total calories.
‡Model 2 adjusted for Model 1 + body mass index + depressive symptoms.
§Model 3 adjusted for Model 1 + cardiovascular conditions (including diabetes, hypertension, stroke and myocardial infarction).