Table 3.
Proportional Hazard Ratios and 95% Confidence Intervals of Estimated Effects of Tertiles of MIND, Mediterranean, and DASH Diet Scores on Time to Incident Disability on Instrumental Activities of Daily Living (n = 471) in Memory and Aging Project Participants Over a Mean 4.2 Years of Follow-up, 2004–2017
| Score Range | No. of Events/N | Model 1† | Model 2‡ | Model 3§ | |
|---|---|---|---|---|---|
| MIND Diet Score | |||||
| T1 | 3.0–7.0 | 177/209 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| T2 | 7.5–8.5 | 105/136 | 0.80 (0.62–1.02) | 0.84 (0.65–1.08) | 0.81 (0.62–1.04) |
| T3 | 9.0–13.0 | 94/126 | 0.79 (0.60–1.03) | 0.79 (0.60–1.04) | 0.81 (0.61–1.07) |
| p trend | .04 | .06 | .09 | ||
| Mediterranean Diet Score | |||||
| T1 | 18–30 | 139/167 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| T2 | 31–34 | 150/182 | 0.99 (0.77–1.26) | 1.01 (0.79–1.29) | 0.99 (0.76–1.28) |
| T3 | 35–46 | 87/122 | 0.76 (0.56–1.01) | 0.75 (0.56–1.01) | 0.86 (0.63–1.18) |
| p trend | .08 | .09 | .40 | ||
| DASH Diet Score | |||||
| T1 | 2.0–3.5 | 160/198 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| T2 | 4.0–4.5 | 101/122 | 1.05 (0.82–1.36) | 1.06 (0.82–1.37) | 1.13 (0.86–1.48) |
| T3 | 5.0–8.5 | 115/151 | 0.81 (0.63–1.04) | 0.81 (0.63–1.05) | 0.86 (0.66–1.12) |
| p trend | .15 | .16 | .39 | ||
Notes: Cox-Proportional hazard model was used. DASH = Dietary Approaches to Stop Hypertension; MIND = Mediterranean–DASH Diet Intervention for Neurodegenerative Delay; T1 = tertile 1; T2 = tertile 2; T3 = tertile 3.
†Model 1 adjusted for age, sex, education, smoking, physical activity, and total calories.
‡˝Model 2 adjusted for Model 1 + body mass index + depressive symptoms.
§Model 3 adjusted for Model 1 + cardiovascular conditions (including diabetes, hypertension, stroke and myocardial infarction).