Figure 5.

Proinflammatory cytokine levels are increased with age in males but enalapril treatment increases anti-inflammatory cytokine levels. Levels of cytokines interleukin (IL)-6, IL-10, IL-12p40, eotaxin, granulocyte-colony stimulating factor (G-CSF), macrophage inflammatory protein (MIP)-1α, monocyte chemoattractant protein (MCP)-1, IL-1β, IL-1α, and IL-4 were assessed in serum from male mice (A–J). Cytokine levels for male mice were assessed in serum at 13 months of age after 4 months of treatment (middle-aged) and at 25 months of age after 7 months of treatment (older). Two-way ANOVA, with post hoc analysis, was used to examine the effect of age and treatment on serum levels of each cytokine. Middle-aged male 8 drug, 9 control; older male 12 drug, 9 control. *p < .05 versus corresponding control group. ^#p < .05 versus corresponding middle-aged group.