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. Author manuscript; available in PMC: 2019 Jul 12.
Published in final edited form as: Biochem Pharmacol. 2018 Nov 10;159:25–31. doi: 10.1016/j.bcp.2018.11.010

Fig. 1.

Fig. 1.

APAP metabolismoverview. Metabolites highlighted in grey are detectable in urine using 1H-NMR. Abbreviations: SULT (sulfotransferase); UGT (uridine 5′-diphospho-glucuronosyltransferase); CYP (cytochrome P450); APAP (acetyl-4-aminophenol); APAP-S (acetyl-4-aminophenol sulfate); APAP-G (acetyl-4-aminophenyl beta-D-glucopyranosiduronic acid); APAP-Cys (3-(5′-acetamido-2′-hydroxyphenyl)-2-aminoproprionic acid); APAP-NAC (2-acetamido-3-(5′-acetamido-2′-hydroxyphenylthio) propanoic acid); GSH (glutathione); NAPQI(N-acetyl-p-benzoquinone imine).