Skip to main content
. Author manuscript; available in PMC: 2019 Jul 12.
Published in final edited form as: Biochem Pharmacol. 2018 Nov 10;159:25–31. doi: 10.1016/j.bcp.2018.11.010

Fig. 3.

Fig. 3.

Mefinfluences APAP metabolism. APAP (1.0 g) was taken alone, white dots, or simultaneously with Mef (0.75 g), black dots. Drugs were taken orally with 275 ml water. Voided urine samples were collected at the indicated time intervals, sample volumes were determined, and APAP metabolite levels were quantitated using NMR (see, NMR Measurements in Methods). Data are plotted as total μmoles of metabolite in a given sample vs the time following drug administration. The influences of Mef on the following conjugates are shown: Panel A, APAP-sulfonate; Panel B, APAP-glucuronide; Panel C, APAP-cysteine; and Panel D, APAP-acetylcysteine.