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The effects of Mef on APAP first-pass metabolism. APAP (1.0 g) was administered orally at t0 with and without Mef (0.75 g). Urine was collected at 30 min and APAP and Mef metabolites were analyzed using 900 MHz 1H NMR (see, Materials and Methods). Spectra with (solid line) and without Mef (dotted line) are overlain, and the metabolite peaks are labelled. In the presence of Mef, the APAP-S peak is suppressed beyond the limit of detection (~100-fold).
