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. 2019 Jul 8;11:6245–6252. doi: 10.2147/CMAR.S197921

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© 2019 Dong et al.

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The structures of YAP and TAZ. YAP has a proline-rich (P-rich) region at the N-terminal, the TEAD transcription factor-binding domain, the WW domain(s) in the middle, followed by an Src homology domain 3 binding motif (SH3 BM), a coiled-coiled motif (CC), and a PDZ-binding motif in the C-terminal. TAZ has a similar domain organization as YAP but lacks the proline-rich domain, the second WW domain, and the SH3-binding motif.

Abbreviations: YAP, Yes-associated protein; TAZ, transcriptional coactivator with PDZ-binding motif.