Fig. 17.3.

A schematic of events leading to formation of pathologic α-synuclein aggregates and their propagation throughout the nervous system. Events that we postulate can occur frequently and in large numbers of normal individuals are depicted in the green box, whereas events with rare occurrences, and associated with the development of α-synucleinpathies, are in the red box. DLB, dementia with Lewy bodies; ILBD, incidental Lewy body disease; MSA, multiple system atrophy; PD, Parkinson disease; PDD, Parkinson disease dementia.