Table 5.
Factors associated with disease-specific survival
| Variable | Univariate | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | p value | Adjusted HR (95% CI) | p value | |
| Median age | 0.98 (0.95 – 1.01) | .162 | ||
| Race | ||||
| White | Referent | -- | -- | -- |
| Black | 1.52 (0.90 – 2.59) | .121 | ||
| Hispanic | 1.23 (0.84 – 1.81) | .279 | ||
| Other | 1.35 (0.77 – 2.36) | .295 | ||
| Histology | ||||
| Squamous cell | Referent | -- | Referent | -- |
| Adenocarcinoma | 0.70 (0.45 – 1.11) | .132 | 1.02 (0.63 – 1.64) | .940 |
| Adenosquamous | 2.41 (1.58 – 3.67) | <.001 | 2.37 (1.55 – 3.63) | <.001 |
| Grade | ||||
| G1 | Referent | -- | Referent | -- |
| G2 | 2.64 (1.06 – 6.61) | .038 | 1.96 (0.76 – 5.08) | .164 |
| G3 | 4.65 (1.88 – 11.48) | .001 | 2.86 (1.11 – 7.51) | .030 |
| Unknown | 1.60 (0.51 – 5.05) | .420 | 1.45 (0.45 – 4.70) | .532 |
| Tumor size | ||||
| ≤ 2 cm | Referent | -- | Referent | -- |
| > 2 cm | 2.56 (1.82 – 3.62) | <.001 | 1.82 (1.26 – 2.62) | .001 |
| Unknown | NE | .962 | NE | .963 |
| Surgery | ||||
| Less radical | Referent | -- | Referent | -- |
| More radical | 1.13 (0.78 – 1.63) | .511 | 0.99 (0.69 – 1.44) | .969 |
| Positive LN | ||||
| No | Referent | -- | Referent | -- |
| Yes | 3.03 (2.16 – 4.24) | <.001 | 2.42 (1.70 – 3.42) | <.001 |
| Unknown if examined | NE | .959 | NE | .988 |
| *RT | ||||
| No | Referent | -- | -- | -- |
| Yes | 3.07 (2.21 – 4.26) | <.001 | ||
| *RT type | ||||
| None | Referent | -- | -- | -- |
| External beam | 3.10 (2.17 – 4.43) | <.001 | ||
| Brachytherapy | 5.50 (2.00 – 15.09) | .001 | ||
| Both | 2.63 (1.55 – 4.49) | <.001 | ||
| RT NOS | 5.35 (0.74 – 38.59) | .096 | ||
Abbreviations: LN, lymph node; RT, radiation therapy; NOS, not otherwise specified; NE = Not estimable
*
Not included in multivariable analysis due to multicollinearity