Table 1:

Variants in SCN10A associated with SUD

Gene variant	Protein	Age	Classification	Sex	Ethnicity	Case Information	Incidence in gnomAD	Other variant(s)
g.38798293G>T	L388M	24 year	VUS	M	African-American	Decedent was playing in fire hydrant, collapsed and died. History of asthma. Autopsy negative	Novel	KCND3-Ala2Glu (VUS) DSP-Val2004Phe (VUS) TRPM4-Ser1143Gly (VUS)
g.38781020G>A	R756W	3 year	VUS	M	African-American	Found face down in partially filled bathtub. Recent gastrointestinal illness	6/23,972 African 9/126,154 European (Non-Finnish) 15/150,126 Total (0.01%)	None
g.38770074G>A	L867F	49 day	VUS	F	Hispanic	It was a sudden, unexpected crib death (found supine). Mother of child is 35Y old with a history of miscarriages. When she was 15Y, she had a baby who died at 2M old which was reported due to “pneumonia” at the time.	7/34,322 Latino 1/24,022 African 8/274,720 Total (0.003%)	None
g.3:38764969G>A	P1102S	2 day	VUS	M	Caucasian	Twin. Decedent was born at 38 weeks gestation. Decedent was noted to be holding his breath while eating, decedent was taken to hospital. Decedent was “floppy” with a faint pulse and agonal respirations.	1/108,936 European (Non-Finnish) 1/243,332 Total (0.0004%)	MYH7 p.Arg1344Gln
g.38743435C>T	V1518I	27 year	VUS	M	African- American	Found unresponsive in bedroom right side up by mother. Slight to moderate four chamber dilation of the heart.	14/24,032 African 1/18,864 East Asian 1/34,410 Latino 3/126,482 European (Non-Finnish) 1/6,464 Other 20/276,950 Total (0.007%)	RyR2 p.Arg3190Gln
g.38743435C>T	V1518I	2 months	VUS	F	Caucasian	Found unresponsive while co-sleeping with mother in adult bed.	See above	None

gnomAD searched on 2017–07–20. Variant classification by ACMG/AMP 2015 guidelines were made on http://wintervar.wglab.org/