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. 2019 Jul 1;13(7):e0007533. doi: 10.1371/journal.pntd.0007533

Fig 7. Synthetic peptide spanning rm-CXCL1 cleavage site inhibits L. major-mediated CXCL1 degradation.

Fig 7

(A) Schematic of synthetic peptide generation. Alignment of full length murine CXCL1 with mature murine CXCL1 demonstrating the schematic for generation of peptide#1, peptide#2 and blocking peptide. Peptide#1 and peptide#2 were generated from the N-terminal region of full length murine CXCL1. Blocking peptide spanning the L. major cleavage site on murine CXCL1 were generated. Lm lysate-mediated degradation of rm-CXCL1 in the presence of (B) Activity of synthetic peptides from (A) in inhibiting L. major-mediated degradation of rm-CXCL1. (C) Model of L. major metalloprotease function on CXCL1 during infection. Data are representative of at least three independent experiments. Results are represented as mean ± SEM. ****P<0.0001.