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. 2019 Jun 18;25(7):408–422. doi: 10.1093/molehr/gaz028

Figure 7.

Figure 7

Regulation interplay of genomic signaling by IL-1 Inline graphic , FSK, and P4. A. Inhibition of the regulatory network induced by IL-1Inline graphic (same network and inputs used for Fig. 5C) by different combinations of P4 and FSK (e.g. an orange node is significant in IL-1Inline graphic versus Ctrl and remains significant in the same direction in P4 + IL-1Inline graphic versus Ctrl but becomes insignificant or significant in the opposite direction in FSK + IL-1Inline graphic versus Ctrl and FSK + P4 + IL-1Inline graphic versus Ctrl). B. Regulatory patterns of P4 and FSK. The network is obtained by performing RNEA for FSK + P4 versus Ctrl with a Inline graphic cutoff of 2.4 and P-value cutoff of 0.05. Node colors are based on P4 versus Ctrl, FSK versus Ctrl, and FSK + P4 versus Ctrl expression comparisons. Node shape indicates differential expression of each node, including direction of regulation. See Supplementary File IV for full RNEA networks for FSK + P4.