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. Author manuscript; available in PMC: 2019 Aug 30.
Published in final edited form as: Stat Med. 2019 May 6;38(19):3599–3613. doi: 10.1002/sim.8185

Table 4.

Simulation results under violation of the independence assumption: Survival and truncation times simulated from a normal copula with correlations ρLT , ρLR, and ρTR, where ρXY denotes the correlation between random variables X and Y. The marginal distributions for the survival, left, and right truncation times are set to gamma(10, 1), gamma(3, 1), and gamma(5, 2) distributions, respectively. Here qL,qR, q are the proportion of observations missing due to left, right, and double (left and right) truncation, respectively. The average observed sample size is n = 250 for all models. F^SP denotes the SPMLE, F^NP denotes the NPMLE, and F^emp denotes the naïve empirical CDF which ignores double truncation. These estimators were all computed at t0.1, …, t0.9, the 1st through 9th deciles of the true survival distribution F0. For a given estimator F^, Bias(F^) is the (absolute) difference between F^ and F0, averaged across the 9 deciles. Here SD(F^) is standard deviation of F^ across simulations, SE^(F^) is estimated standard error of F^, MSE(F^) is mean squared error of F^, and Cov(F^) is 95% coverage, all averaged across the 9 deciles. Here t^0.5 is the estimated median value based on F^. The true median value based on F0 is t0.5 = 9:7. Here Bias(t^0.5) = t^0.5 - t0.5 and SD(t^0.5) is the standard deviation of t^0.5 across simulations.

Model ρLT, ρLR, ρRT qL, qR, q Estimator Bias(F^) SD(F^) SE^(F^) MSE(F^) Cov(F^) Bias(t^0.5) SD(t^0.5)
F^SP 0.049 0.038 0.046 0.005 0.744 −0.458 0.343
7 0.5,0.1,0.1 0.09,0.35,0.43 F^NP 0.055 0.038 0.024 0.005 0.380 −0.507 0.332
F^emp 0.102 0.025 0.020 0.012 0.315 −0.896 0.202
F^SP 0.042 0.033 0.046 0.004 0.701 0.336 0.268
8 −0.5,0.1,−0.1 0.22,0.37,0.56 F^NP 0.044 0.034 0.022 0.004 0.447 0.374 0.276
F^emp 0.068 0.023 0.018 0.006 0.293 −0.285 0.171
F^SP 0.119 0.029 0.058 0.018 0.478 −0.968 0.218
9 −0.1,0.1,−0.5 0.18,0.39,0.55 F^NP 0.121 0.029 0.026 0.018 0.101 −0.982 0.223
F^emp 0.124 0.022 0.017 0.021 0.262 −0.942 0.156
F^SP 0.083 0.027 0.055 0.010 0.579 −0.503 0.189
10 −0.5,0.1,−0.5 0.22,0.39,0.58 F^NP 0.079 0.028 0.025 0.009 0.279 −0.488 0.195
F^emp 0.106 0.021 0.017 0.016 0.223 −0.638 0.146