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. Author manuscript; available in PMC: 2020 Jul 11.
Published in final edited form as: Mol Cell. 2019 May 2;75(1):154–171.e5. doi: 10.1016/j.molcel.2019.04.014

Figure 7. Conservation of CTCF- and TF-mediated DNA loops from gametes through preimplantation embryos.

Figure 7.

(A) Metaplot showing median, distance-normalized Hi-C of sperm, GV oocytes, and allele-specific preimplantation embryos at loops defined in paternal PN5 chromosomes using a derivative of the HiCCUPS method. The bottom row shows the difference between paternal and maternal median, distance-normalized Hi-C interactions.

(B) Metaplot showing median, distance-normalized Hi-C of sperm, GV oocytes, and allele-specific preimplantation embryos at loops defined in maternal PN5 chromosomes using a derivative of the HiCCUPS method. The bottom row gives the difference between paternal and maternal median, distance-normalized Hi-C interactions.

(C) Metaplot showing median, distance-normalized Hi-C of sperm, GV oocytes, and allele-specific preimplantation embryos at Foxa1-mediated enhancer-promoter significant interactions determined by FitHi-C.

See also Figure S7