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. Author manuscript; available in PMC: 2019 Oct 9.
Published in final edited form as: Oncogene. 2019 Apr 9;38(28):5599–5611. doi: 10.1038/s41388-019-0811-9

Figure 1. Mst1r Promotes Pancreatic Cancer Initiation and Progression.

Figure 1.

(A) Low grade PanIN in a 6m KC mouse (B) Expansive PanIN formation in 6m KRC mouse. (C) Immunofluorescent staining for amylase (red, acini) and CK19 (green, ductal epithelium), confirming ADM within lesions of KRC pancreata (arrows). (D) Representative section from 6m KRC pancreas demonstrating sporadic areas of increased Mst1r expression (red) that correlate with nuclear expression of Pdx-1 (green), indicating the presence of the Pdx-1-Mst1r transgene. (E) Representative sections of KC, KRC and KTK−/−C pancreata demonstrates that KRC develop earlier onset of high grade PanIN2 and 3 compared to KC controls and KTK−/−C pancreata. (F) KRC animals have decreased survival compared with KC controls. Median survival 47 weeks (95% confidence interval 43–51 weeks) KC littermates failed to reach median survival in this cohort, p=0.004. (G) KTK−/−C animals have increased survival compared with KC controls. Median survival 63 weeks in KTK−/−C animals vs. 53 weeks in KC animals p=0.02 (Log-rank (Mantel-Cox) test).