Table 2.
Annual percent changes in age-standardized hepatocellular carcinoma incidence rates by hepatitis C and B viral status in SEER-Medicare, 2001–2013
| All HCC Cases | HCV-attributable HCC Cases | HBV-attributable HCC Cases | HCV/HBV-unrelated HCC Cases | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Demographic | 2001 Rate | 2013 Rate | APC (95% CI) | 2001 Rate | 2013 Rate | APC (95% CI) | 2001 Rate | 2013 Rate | APC (95% CI) | 2001 Rate | 2013 Rate | APC (95% CI) |
| Total | 16.3 | 23.3 | 3.40 (2.80–4.01) | 4.19 | 8.20 | 5.62 (4.50–6.76) | 1.32 | 1.78 | 3.17 (1.66–4.71) | 11.3 | 14.1 | 2.35 (1.55–3.16) |
| Sex | ||||||||||||
| Male | 27.7 | 36.6 | 3.16 (2.50–3.82) | 6.34 | 11.9 | 6.11 (4.55–7.68) | 2.00 | 2.93 | 2.86 (1.00–4.76) | 20.1 | 23.2 | 2.05 (1.09–3.01) |
| Female | 8.77 | 13.4 | 3.14 (2.19–4.11) | 2.69 | 5.26 | 4.37 (2.82–5.95) | 0.82 | 0.91 | 3.39 (1.38–5.45) | 5.68 | 7.55 | 2.18 (1.26–3.10) |
| Age group, years | ||||||||||||
| 66–75 | 9.92 | 13.6 | 3.20 (2.42–3.99) | 3.11 | 5.66 | 5.43 (4.09–6.78) | 1.16 | 1.13 | 1.48 (−0.46–3.46) | 6.12 | 7.37 | 1.96 (0.84–3.09) |
| 76–85 | 5.26 | 8.44 | 3.86 (3.17–4.55) | 0.93 | 2.38 | 6.24 (4.22–8.31) | ~ | 0.61 | 6.54 (2.95–10.3) | 4.25 | 5.70 | 2.90 (2.22–3.59) |
| 86+ | 1.11 | 1.25 | 2.76 (0.91–4.65) | ~ | 0.16 | 4.45† (−0.56–9.72) | ~ | ~ | n.e. | 0.96 | 1.05 | 2.21 (0.39–4.06) |
| Race/ethnicity | ||||||||||||
| White | 12.8 | 19.7 | 3.69 (3.16–4.22) | 2.58 | 5.80 | 6.30 (5.09–7.53) | 0.52 | 0.58 | 2.14 (0.01–4.31) | 9.98 | 13.6 | 2.92 (2.18–3.66) |
| Black | 21.6 | 28.1 | 4.21 (1.91–6.56) | 8.93 | 19.4 | 9.04 (6.30–11.9) | ~ | ~ | 3.73 (−3.44–11.4) | 12.4 | 8.04 | −0.87 (−4.00–2.35) |
| Asian | 62.2 | 54.8 | −0.35 (−1.84–1.15) | 25.1 | 23.7 | −0.61 (−2.17–0.97) | 16.9 | 19.5 | 1.06 (−1.21–3.38) | 26.0 | 20.2 | −1.52 (−3.48–0.48) |
| Hispanic | 32.2 | 39.1 | 3.62 (0.99–6.31) | ~ | 14.3 | 6.01 (0.68–11.6) | ~ | ~ | 6.76 (−2.05–16.4) | 25.2 | 24.9 | 2.37 (−0.46–5.28) |
| Other/unknown | 29.5 | 34.6 | 0.05 (−2.47–2.64) | ~ | 10.4 | 0.77 (−3.24–4.95) | ~ | 4.84 | 0.48 (−3.84–5.01) | 18.6 | 20.7 | −0.99 (−3.80–1.90) |
HCC: hepatocellular carcinoma; HCV: hepatitis C virus, HBV: hepatitis B virus, APC: annual percent change, CI: confidence interval
Statistically significant APCs are denoted in bold text.
†
APCs are shown for the entire 2001–2013; however, a statistically significant joinpoint for APC was detected for HCV-attributable HCC rates among 86+ year-olds (2001–04: −17.6%/year; 2004–08: 30.1%/year; 2008–13: −7.71%/year) and for HBV-attributable HCC rates among females (2001–04: −8.53%years; 2004–09: 11.0%/year; 2009–13: −2.73%/year).
~
Incidence rates with <11 cases were suppressed.