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. 2019 Apr 16;12(4):e002471. doi: 10.1161/CIRCGEN.119.002471

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© 2019 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — Association between chromosome 9p21 and subsequent coronary heart disease (CHD) events in all participants with baseline CHD (GENIUS-CHD [Genetics of Subsequent Coronary Heart Disease]) compared with association in CHD cases and CHD-free controls (CARDIoGRAMPlusC4D). For the CARDIoGRAMPlusC4D consortium (Coronary Artery Disease Genome wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) meta-analysis estimate, 6 studies (LURIC, LIFE-Heart [The Leipzig Heart Study], GoDARTS [Genetics of Diabetes Audit and Research in Tayside Scotland], OHGS [Ottawa Heart Genomics Study], PROSPER [Prospective Study of Pravastatin in the Elderly at Risk], WTCCC [Welcome Trust Case Control Consortium]) were excluded as they were also included in GENIUS-CHD. Estimates for GENIUS-CHD are also presented by subtype of CHD at baseline, including acute coronary syndrome (ACS), stable coronary artery disease (CAD) without prior myocardial infarction (MI; CAD/no MI), and stable CAD with prior MI (CAD/MI). All estimates were adjusted for age and sex.