. Author manuscript; available in PMC: 2020 Jul 12.

Published in final edited form as: ACS Infect Dis. 2019 May 1;5(7):1231–1238. doi: 10.1021/acsinfecdis.9b00071

Table 1.

Biochemical activities of oxaboroles with MIC values <10 μg/mL

Compound	IC₅₀ (μM)^a	MIC^b MRSA (μg/mL)	Cytotoxicity^c Vero cells (IC₅₀ μg/mL)
PT649	94 ± 2	6.25	N.D.
PT638	>100	0.4	≥100
PT650	>100	1.56	N.D.
PT659	>100	6.25	N.D.
PT662	3.0 ± 1.2	3.125	≥100
PT660	28 ± 1	6.25	N.D.

IC₅₀ values were measured by means of a radiolabeled LeuRS aminoacylation assay.

MIC against MRSA ATCC BAA-1762 was determined using a broth microdilution method.

Cytotoxicity was determined with Vero cells using an MTT cell viability assay. All measurements were performed in triplicate and standard errors are reported.

N.D., not determined.