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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Cancer Genet. 2019 Apr 13;235-236:31–38. doi: 10.1016/j.cancergen.2019.04.005

Table 3.

Logistic regression analysis of relationships between clinical factors and risk of carrying a likely-somatic variant, adjusting for personal cancer history, age at testing, germline pathogenic variant carrier status, and clinical indication for testing. (All tested individuals; N=348,543.)

Variable Odds ratio 95% confidence limits p-value
Personal Cancer History (affected versus unaffected) 3.3 (2.7, 4.0) <0.001
Age at Testing (≥50 years versus <50 years) 3.1 (2.5, 3.7) A <0.001
Germline PV Carrier Status (positive versus negative/VUS) 1.2 (0.9, 1.5) 0.203

PV, Pathogenic variant; VUS, Variant of uncertain significance.