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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: J Magn Reson Imaging. 2019 Jan 20;50(2):347–364. doi: 10.1002/jmri.26645

Figure 5.

Figure 5.

a: Conventional and APTw MRI and histology from a patient with tumor progression. The gadolinium-enhancing areas on Gd-T1w were hyperintense on the APTw images, compared with the contralateral brain area. H&E-stained section demonstrated spindle mesenchymal cell proliferation with segregated glial cells. b: Conventional and APTw MRI and histology from a patient with the clinical diagnosis of pseudoprogression. The gadolinium-enhancing lesion appeared isointense on APTw, with punctate APTw hyperintensity scattered within the lesion. H&E-stained section showed large necrosis with scattered dying tumor cells and inflammatory cells. For APTw images (display window −5% to 5%), 15 slices were acquired, and only one is shown. Reproduced with permission, and with the addition of pathology images, from Ma et al., J Magn Reson Imaging 2016;44:456–62.