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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2019 Jan 11;192:105283. doi: 10.1016/j.jsbmb.2019.01.001

Figure 7.

Figure 7.

Inhibition of AR Reporter Gene Assays by Lead Compounds. The ability of compounds to inhibit AR transcriptional activity induced by 0.1 nM DHT in HeLa cells cells that are stably transfected with the AR and a luciferase reporter gene (HeLa-AR3A-PSA-(ARE)4-Luc13 cell, Hela-13) were used for this assay. The luciferase activity was measured in (1.5 × 104) cells incubated in the presence of 0.1 nM DHT in the presence and absence of increasing concentrations of the drug shown. Enzalutamide (◆); R-biaclutamide ( ∇ ); compound 1 (•); GTX-560 (∎) ); ASP9521 (●) and Abiraterone (X). Mean + SD (n=3)