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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2019 Jan 11;192:105283. doi: 10.1016/j.jsbmb.2019.01.001

Table 1.

Inhibitory Properties of Compounds on Other Human AKR1C Enzymes

Compound IC50 values (μM)
AKR1C3 AKR1C1 AKR1C2 AKR1C4
1 0.086 ± 0.011 41.3 ± 1.64 24.7 ± 1.07 30.6 ± 3.87
3 0.053 ± 0.002 15.4 ± 1.9 15.6 ± 1.1 5.34 ± 0.29
4 0.082 ± 0.006 50.0 ± 3.89 19.5 ± 0.47 17.7 ± 2.08

All values are mean + SE (n= 3)