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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Nature. 2019 May 1;569(7755):265–269. doi: 10.1038/s41586-019-1165-8

Extended Data Fig. 9. A working model for the role of the coiled coil protein FLL2 to promote nuclear bodies important for polyadenylation at specific sites.

Extended Data Fig. 9

At efficient polyA sites, the cleavage and polyadenylation specificity factor (CPSF) complex specifically recognizes the cis-acting motif upstream of the cleavage site, catalyzes pre-mRNA cleavage, and recruits polyA polymerase to initiate polyadenylation. At other sites, phase-separated FCA droplets compartmentalize 3’ end processing factors to enhance polyadenylation.