Table 5.
Cytotoxic activity of maprang seed extracts against human cancer cell lines (K562 and its P-gp over-expressed K562/adr, GLC4 and its MRP-1 over-expressed GLC4/adr).
| Cell line |
IC50 (μg/mL) Mean ± SD (n = 3) |
Resistance Factor RF = (IC50 resistant cell/IC50 sensitive cell) |
||||||
| MPWG25 |
MPWG50 |
MPWG75 |
MPWG95 |
MPWG25 |
MPWG50 |
MPWG75 |
MPWG95 |
|
| K562 | 25.22 ± 0.40 | 13.43 ± 1.08 | 15.57 ± 0.92 | 14.75 ± 0.25 | - | - | - | - |
| K562/adr | 21.19 ± 0.53 | 13.88 ± 0.43 | 10.87 ± 0.22 | 14.75 ± 0.38 | 0.84 | 1.03 | 0.70 | 1 |
| GLC4 | 16.90 ± 0.30 | 9.60 ± 0.57 | 4.43 ± 0.39 | 3.56 ± 0.25 | - | - | - | - |
| GLC4/adr |
4.84 ± 0.14 |
8.31 ± 0.25 |
8.72 ± 0.84 |
8.30 ± 0.28 |
0.28 |
0.86 |
1.97 |
2.33 |
| MPPG25 |
MPPG50 |
MPPG75 |
MPPG95 |
MPPG25 |
MPPG50 |
MPPG75 |
MPPG95 |
|
| K562 | 16.90 ± 0.41 | 5.00 ± 0.19 | 13.5 ± 0.33 | 36.00 ± 0.74 | - | - | - | - |
| K562/adr | 16.00 ± 0.57 | 2.70 ± 0.15 | 9.40 ± 0.20 | 18.80 ± 0.48 | 0.95 | 0.54 | 0.70 | 0.52 |
| GLC4 | 12.90 ± 0.62 | 2.70 ± 0.18 | 6.80 ± 0.13 | 15.50 ± 0.23 | - | - | - | - |
| GLC4/adr |
6.00 ± 1.07 |
1.96 ± 0.15 |
2.70 ± 0.25 |
11.32 ± 0.20 |
0.46 |
0.73 |
0.40 |
0.73 |
| MYCG25 |
MYCG50 |
MYCG75 |
MYCG95 |
MYCG25 |
MYCG50 |
MYCG75 |
MYCG95 |
|
| K562 | 43.90 ± 1.33 | 35.34 ± 0.80 | 16.43 ± 0.98 | 13.42 ± 0.29 | - | - | - | - |
| K562/adr | 27.62 ± 1.00 | 26.30 ± 0.52 | 11.28 ± 0.42 | 13.00 ± 0.10 | 0.63 | 0.74 | 0.68 | 0.97 |
| GLC4 | 23.33 ± 0.65 | 10.46 ± 0.86 | 10.45 ± 0.22 | 3.56 ± 0.10 | - | - | - | - |
| GLC4/adr | 8.30 ± 0.17 | 10.00 ± 0.58 | 6.16 ± 0.15 | 8.30 ± 0.18 | 0.35 | 0.96 | 0.59 | 2.33 |