Table 2.
Laboratory Findings of β thalassemia intermedia cohort in Sri Lanka.
| Laboratory Findings | All β thalassemia intermedia n = 50 Median (IQR) |
β thalassemia intermedia disease severity | P value | ||
|---|---|---|---|---|---|
| Mild n = 26 Median (IQR) |
Moderate n = 12 Median (IQR) |
Severe n = 12 Median (IQR) |
|||
| Hb at first presentation (g/dl) |
(n = 45) 7.3 (6.2–8.5) |
(n = 26) 7.6 (6.8–8.7) |
(n = 10) 6.8 (6.0–8.2) |
(n = 9) 7.0 (5.6–8.1) |
0.725 |
| Steady state Hb (g/dl) |
(n = 49) 7.9 (6.9–8.3) |
(n = 25) 8.1 (7.8–9.0) |
(n = 12) 7.1 (6.6–7.8) |
(n = 12) 7.7 (6.8–8.0) |
0.001 |
| MCV (fl) |
(n = 50) 67.8 (62.6–74.9) |
(n = 26) 64.5 (60.2–70.0) |
(n = 12) 75.0 (66.5–81.3) |
(n = 12) 68.4 (67.3–76.4) |
0.077 |
| MCH (pg) |
(n = 50) 21.8 (20.3–25.1) |
(n = 26) 20.8 (19.8–23.0) |
(n = 12) 25.4 (22.0–27.3) |
(n = 12) 21.2 (20.0–25.2) |
0.029 |
| HPLC: HbA2 (%) |
(n = 48) 4.6 (3.6–5.2) |
(n = 25) 4.7 (3.3–5.6) |
(n = 12) 4.6 (3.7–5.2) |
(n = 11) 4.5 (2.8–5.0) |
0.555 |
| HPLC: HbF (%) |
(n = 49) 5.8 (1.8–16.3) |
(n = 26) 4.6 (1.6–18.6) |
(n = 12) 2.9 (1.4–10.0) |
(n = 11) 10.1 (6.7–94.6) |
0.041 |
| Reticulocyte count (%) |
(n = 45) 2.0 (1.6–3.1) |
(n = 25) 2.0 (1.8–2.8) |
(n = 10) 3.1 (1.6–3.6) |
(n = 10) 1.8 (1.0–3.2) |
0.376 |
| HbF cell count (%) |
(n = 46) 2.6 (1.2–9.3) |
(n = 25) 2.0 (1.2–12.2) |
(n = 12) 2.6 (1.2–5.4) |
(n = 9) 6.0 (1.2–90.0) |
0.507 |
| Ferritin (ng/ml) |
(n = 48) 294.8 (147.2–503.6) |
(n = 25) 168.0 (62.3–294.3) |
(n = 12) 406.9 (301.4–821.3) |
(n = 11) 477.1 (292.0–670.6) |
0.001 |
Data are median (IQR) or number (%).