Fig. 4.
Optogenetic suppression of A1 impairs auditory spatial learning. a Sound localization in the session before the right ear was plugged shown by plotting the mean proportion of correct scores (and 95% confidence intervals) for 1000 ms bursts of broadband noise at each of 12 loudspeakers positioned at equal intervals in the horizontal plane (0° is directly in front). Data are from ferrets in which left A1 activity was suppressed by illumination of ArchT during each stimulus presentation (green, n = 13) and from a control group (black, n = 13). b Proportion of correct responses (averaged across all speaker locations) achieved by each animal in both groups in the Pre-plug session, on each of the 10 days over which the plug was worn (days 1–10), and in the session following its removal (Post-plug). c The difference in adaptation rate between these groups is shown by plotting the proportion of correct responses for the first 2 days and the last 2 days of monaural occlusion (ANOVA, F3,100 = 62.531, P < 0.0001, post hoc Scheffé test, ** indicates P ≤ 0.01). d Magnitude of the localization errors on incorrect trials before, during and after this period of monaural occlusion. Symbols in (b) and (d) represent data from individual animals, and the lines and shaded areas are the best linear fits and 95% confidence intervals of these fits, respectively, over the 10 days of monaural occlusion. Source data are provided as a Source Data file