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. 2019 Jul 12;10:3085. doi: 10.1038/s41467-019-11083-2

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

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Fig. 1 — Overall structure of the D1D2:dsRNA:D1D2 assembly of human DDX3X. a Domain structure of human DDX3X and conserved sequence motifs of DDXs. The minimal active construct of DDX3X helicase core (the D1D2 core, residues 132–607) is used for structural studies. The 12 highly conserved DDX sequence motifs are color coded: red, ATP binding; blue, RNA binding; and orange, coordination between ATP and RNA binding. b Crystal structure of the D1D2:dsRNA:D1D2 assembly in two views. The complex contains two D1D2 cores (cyan/orange) and a 23-bp double-stranded RNA (dsRNA) (blue/red). c The D1D2:dsRNA:D1D2 structure fits well in the SAXS ab initio envelope. d Overlay of experimental scattering profiles (black) with back-calculated scattering profiles (red) for the D1D2:dsRNA:D1D2 complex. The inset shows the overlay of the crystal structure (red) with experimental (black) pair-distance distribution functions (PDDFs). Source data are provided as a Source Data file