Table 1.
Interactors of β-catenin detected by MS.
| Protein name |
Σ# Unique |
Heavy/light SILAC ratio |
p-value | |||
|---|---|---|---|---|---|---|
| Accession | Peptides | Replicate 1 | Replicate 2 | Replicate 3 | ||
| Known interactors | ||||||
| P35221 | Catenin alpha-1 | 33 | 0.003 | 0.003 | 0.001 | 6.71E-07 |
| O60716 | Catenin delta-1 | 4 | 0.002 | 0.002 | 0.001 | 1.07E-07 |
| Q14192 | Four and a half LIM domains protein 2 | 13 | 0.001 | 0.001 | 0.001 | 7.27E-10 |
| O14745 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | 5 | 0.025 | 0.001 | 0.001 | 7.15E-05 |
| Q9Y265 | RuvB-like 1 | 19 | 0.004 | 0.002 | 0.001 | 8.86E-07 |
| P63208 | S-phase kinase-associated protein 1 | 3 | 0.001 | 0.020 | 0.015 | 3.81E-05 |
| COPI subunits | ||||||
| P53621 | Coatomer subunit alpha | 19 | 0.002 | 0.297 | 0.001 | 1.44E-02 |
| P53618 | Coatomer subunit beta | 7 | 0.001 | 0.472 | 0.001 | 4.17E-02 |
| P35606 | Coatomer subunit beta' | 7 | 0.001 | 0.001 | 0.001 | 1.25E-09 |
| P48444 | Coatomer subunit delta | 6 | 0.628 | 0.035 | 0.260 | 8.66E-02 |
| O14579 | Coatomer subunit epsilon | 3 | 0.001 | 0.444 | 0.001 | 3.62E-02 |
| Q9Y678 | Coatomer subunit gamma-1 | 11 | 0.727 | 0.436 | 0.001 | 1.58E-01 |
| P61923 | Coatomer subunit zeta-1 | 3 | 0.460 | 0.462 | 0.423 | 1.67E-03 |
Known interactors (accounting for < 2% of the candidate list) and novel candidate interactor COPI of which all subunits were detected.
β-catenin at the Golgi.