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. Author manuscript; available in PMC: 2020 Apr 19.
Published in final edited form as: Behav Brain Res. 2018 Dec 31;362:7–20. doi: 10.1016/j.bbr.2018.12.052

Figure 4. GABAergic synaptic proteins gephyrin, VGAT and GABAAγ2 were significantly increased after transduction of hippocampal neurons with AAV-NLGN2.

Figure 4.

A, Western blots showing bands for gephyrin, VGAT, GABAAγ2, and actin in hippocampal membrane fractions from mice receiving stereotaxic injections of the AAV-NLGN2 or AAV-mCherry vectors into the hippocampus. B, Total membrane levels of gephyrin were significantly increased after transduction with the AAV-NLGN2 vector, compared to the AAV-mCherry vector (p=0.032, Student’s t-test). C, Total membrane levels of VGAT protein were significantly increased after transduction with the AAV-NLGN2 vector, compared to the AAV-mCherry vector (p=0.0097, Student’s t-test). D, Total membrane levels of GABAAγ2 were significantly increased after transduction with AAV-NLGN2, compared to the AAV-mCherry vector (p=0.016, Student’s t-test).