Table 2.

Cigarette Smoking Characteristics and Associations with Head and Neck Cancer Risk, INHANCE Consortium, 1981–2007

	White				Black
Cigarette Use Characteristic	Cases	%	Controls	%	Adjusted ORa	Adjusted 95% CI	Sensitivity Analysis Adjusted ORa,e	Sensitivity Analysis Adjusted 95% CI	Cases	%	Controls	%	Adjusted ORa	Adjusted 95% CI	Sensitivity Analysis Adjusted ORa,e	Sensitivity Analysis Adjusted 95% CI	LRT p-valuef
Cigarette Smoking
Never	1203	18.2	3308	38.8	1		1		93	9.6	372	39.0	1		1		<0.0001
Ever	5395	81.8	5224	61.2	1.79	1.65–1.95	2.08	1.88–2.30	880	90.4	581	61.0	2.52	1.87–3.39	2.47	1.77–3.45
Missing	1		1						2		0
Cigarette Smoking Status
Never	1203	18.2	3308	38.8	1		1		93	9.6	372	39.0	1		1		0.048
Former	1740	26.4	3358	39.4	1.09	0.98–1.20	1.14	1.01–1.29	173	17.8	281	29.5	1.25	0.87–1.80	1.13	0.75–1.71
Current	3654	55.4	1866	21.9	3.39	3.07–3.75	4.18	3.72–4.70	707	72.7	300	31.5	3.82	2.77–5.27	3.89	2.71–5.58
Missing	2		1						2		0
Smoking Frequencyb
Never	1203	18.2	3308	38.8	1		1		93	9.6	372	39.2	1		1		<0.0001
1–10	493	7.5	1121	13.2	1.08	0.95–1.23	1.05	0.90–1.24	198	20.5	251	26.5	1.58	1.11–2.24	1.48	1.00–2.20
11–20	1817	27.6	2039	23.9	1.80	1.62–1.99	2.06	1.83–2.32	366	37.9	220	23.2	2.78	1.95–3.94	2.83	1.91–4.18
21–30	1180	18.0	857	10.1	2.65	2.33–3.01	3.31	2.86–3.83	137	14.2	53	6.0	5.11	3.20–8.17	4.95	2.96–8.29
>30	1880	28.6	1197	14.1	2.66	2.37–2.99	3.26	2.85–3.74	173	18.0	52	5.5	4.76	2.94–7.70	3.85	2.23–6.64
Missing	26		11						8		5
Smoking Durationc
Never	1187	18.1	3291	38.6	1		1		87	9.1	372	39.2	1		1		<0.0001
1–10	304	4.6	819	9.6	0.93	0.80–1.09	0.80	0.65–0.99	16	1.7	81	8.5	0.68	0.36–1.30	0.65	0.31–1.36
11–20	408	6.2	970	11.4	1.00	0.87–1.15	1.14	0.96–1.36	47	4.9	99	10.4	1.35	0.83–2.21	1.33	0.76–2.32
21–30	899	13.7	1209	14.2	1.51	1.34–1.70	1.70	1.47–1.96	196	20.5	148	15.6	2.37	1.60–3.52	2.11	1.35–3.30
>30	3774	57.4	2228	26.2	3.01	2.73–3.33	3.57	2.18–4.01	612	63.9	249	26.2	4.53	3.22–6.39	4.14	2.84–6.04
Missing	27		16						17		4
Cumulative Smokingd
Never	1203	18.3	3308	38.9	1		1		93	9.7	372	39.2	1		1		0.016
1–10	430	6.6	1181	13.9	0.92	0.81–1.05	0.83	0.70–0.99	86	9.0	179	18.9	1.19	0.80–1.79	1.13	0.71–1.80
11–20	398	6.1	792	9.3	1.19	1.03–1.38	1.30	1.09–1.55	112	11.7	129	13.6	1.66	1.10–2.52	1.73	1.08–2.76
21–30	523	8.0	779	9.2	1.46	1.27–1.68	1.65	1.40–1.96	135	14.1	92	9.7	2.61	1.71–4.00	2.36	1.46–3.82
>30	4007	61.1	2453	28.8	2.83	2.57–3.123	3.45	3.08–3.86	529	55.4	176	18.6	5.27	3.68–7.55	4.87	3.27–7.24
Missing	38		20						20		5
Years Since Quitting
Never Smoked	1203	18.2	3308	38.8	1		1		93	9.6	372	39.0	1		1		0.231
Current Smoker	3654	55.4	1866	21.9	3.61	3.27–3.99	4.41	3.93–4.96	707	72.7	300	31.5	4.10	2.96–5.68	3.93	2.72–5.67
1–10	675	10.2	832	9.8	1.68	1.47–1.92	1.85	1.58–2.16	98	10.1	97	10.2	1.90	1.24–2.93	1.71	1.05–2.77
11–20	508	7.7	1027	12.0	1.09	0.95–1.25	1.12	0.95–1.32	41	4.2	78	8.2	0.94	0.55–1.59	0.76	0.41–1.42
21–30	329	5.0	847	9.9	0.84	0.72–0.98	0.84	0.62–1.02	19	2.0	59	6.2	0.78	0.40–1.49	0.88	0.43–1.78
>30	227	3.4	652	7.6	0.73	0.61–0.88	0.76	0.62–0.95	15	1.5	47	4.9	0.67	0.32–1.38	0.51	0.22–1.20
Missing	3		1						2		0

^aOdds ratios adjusted for age, sex, study center, educational level, frequency of alcohol use (mL of ethanol per day, continuous), duration of cigar smoking (years, continuous), and duration of pipe smoking (years, continuous).

^bin cigarettes/day

^cin years

^din pack-years

^eOdds ratio and 95% CI calculated after exclusion of all oro-pharyngeal cancer cases

^fThis p-value reflects the LRT between the each cigarette smoking characteristic and race within all HNC