Table 3.

Alcohol Use Characteristic and Associations with Head and Neck Cancer Risk, INHANCE Consortium, 1981–2007

	White				Black
Alcohol Use Characteristic	%	Cases	Controls	%	Adjusted ORa	Adjusted 95% CI	Sensitivity Analysis Adjusted ORa,f	Sensitivity Analysis Adjusted 95% CI	Cases	%	Controls	%	Adjusted ORa	Adjusted 95% CI	Sensitivity Analysis Adjusted ORa,r	Sensitivity Analysis Adjusted 95% CI	LRT p-valueg
Alcohol Useb
Never	13.1	863	2028	23.8	1		1		70	7.2	273	28.7	1		1		0.0001
Ever	86.9	5730	6502	76.2	1.57	1.42–1.73	1.58	1.42–1.77	902	92.8	679	71.3	2.85	2.08–3.91	2.86	2.01–4.07
Missing		6	3						3		1
Alcohol Use Status
Never	14.7	826	1912	25.8	1		1		62	8.0	231	31.2	1		1		<0.0001
Former	26.9	1513	1699	22.9	1.55	1.40–1.72	1.58	1.40–1.79	246	31.9	208	28.1	2.95	2.03–4.29	3.26	2.14–4.97
Current	58.5	3296	3808	51.3	1.74	1.53–1.97	1.72	1.49–2.00	463	60.1	302	40.8	2.39	1.62–3.53	2.41	1.55–3.74
Missing		964	1114						204		212
Number of Drinks/Dayc
Never	13.7	863	2028	24.5	1		1		70	7.6	273	29.3	1		1		<0.0001
>0 to <1	29.6	1868	3822	46.3	1.13	1.02–1.26	1.13	1.00–1.28	166	18.0	368	39.5	1.39	0.96–2.00	1.49	0.98–2.26
≥1 to <3	22.1	1392	1427	17.3	2.06	1.81–2.34	2.14	1.83–2.48	203	22.0	155	16.7	3.52	2.31–5.37	3.83	2.37–6.19
≥3 to <5	12.0	755	433	5.2	3.28	2.76–3.89	3.64	2.98–4.45	117	12.7	51	5.5	4.21	2.44–7.28	4.67	2.51–8.69
≥5	22.6	1426	553	6.7	4.46	3.80–5.25	5.26	4.36–6.34	368	39.8	84	9.0	7.70	4.92–12.06	7.20	4.37–11.87
Missing		295	270						51		22
Amount per Dayd
Never	13.7	863	2028	24.5	1		1		70	7.6	273	29.3	1		1		<0.0001
>0 to ≤3	8.6	544	1330	16.1	1.00	0.87–1.15	1.04	0.88–1.22	42	4.6	144	15.5	0.83	0.50–1.40	0.95	0.53–1.70
>3 to ≤18	23.6	1489	2718	32.9	1.26	1.12–1.41	1.24	1.09–1.42	148	16.0	244	26.2	1.91	1.30–2.81	1.93	1.24–3.01
>18	54.1	3408	2187	26.5	2.80	2.49–3.15	2.98	2.60–3.41	664	71.9	270	29.0	5.50	3.80–7.95	5.59	3.69–8.47
		295	270						51		22
Alcohol Duratione
Never	15.2	863	2028	26.7	1				70	9.0	273	34.8	1		1		<0.0001
>0 to <20	10.5	596	1002	13.2	1.35	1.17–1.56	1.39	1.17–1.65	51	6.5	106	13.5	1.34	0.82–2.21	1.54	0.88–2.70
≥20 to <30	15.0	854	979	12.9	1.80	1.56–2.07	1.81	1.56–2.14	126	16.1	96	12.2	3.24	2.04–5.14	3.14	1.81–5.46
≥30 to <40	22.7	1294	1410	18.6	1.87	1.65–2.13	1.81	1.56–2.12	206	26.4	112	14.3	3.94	2.54–6.11	4.38	2.66–7.21
≥40	36.6	2083	2169	28.6	1.78	1.58–2.01	1.91	1.67–2.19	328	42.0	198	25.2	3.27	2.20–4.87	3.30	2.14–5.10
Missing		909	945						194		168

^aOdds ratios adjusted for age, sex, study center, educational level, pack-years of smoking, duration of cigar smoking (years), and duration of pipe smoking (years).

^bDrinking status with 15.6 mL of ethanol in lifetime

^c1 drink = 15.6 mL of ethanol

^din mL

^ein years

^fOdds ratio and 95% CI calculated after exclusion of all oro-pharyngeal cancer cases

^gThis p-value reflects the LRT between each cigarette smoking characteristic and race within all HNC