Table 3.

HUVEC Nanostring: IPA® upstream regulator analysis predicted that endotoxin, cytokine, and TLR signaling regulators are inhibited by apabetalone

IPA upstream regulators
Ingenuity® Pathway Analysis	Target	z-score
		TNFα	Apabetalone 5 μM	Apabetalone 20 μM
Endotoxin	LPS	6.3	− 3.3	− 4.4
Cytokines	TNFα	6.1	− 2.6	− 4.2
	NF-κB (complex)	5.9	− 2.7	− 3.5
	IL-1β	5.4	− 1.9	− 3.3
	IL-1α	4.9	− 2.2	− 1.8
	RELA	4.8	− 1.9	− 2.7
	IFNG	4.3	− 2.9	− 4.0
	IL-6	2.6	− 1.6	− 1.5
TLR signaling	TLR4	5.3	− 3.3	− 4.4
	TICAM1	5.1	− 2.7	− 4.5
	MYD88	5.1	− 3.1	− 4.1
	TLR3	5.0	− 3.3	− 3.5

Positive activation z-scores reflect the predicted activation of an upstream regulator (significant when > ~ 2)

Negative activation z-scores reflect the predicted inactivation of an upstream regulator (significant when < ~− 2)