Table 4.

HUVEC Nanostring: IPA® canonical pathway analysis identified TNFα-activated pathways inhibited by apabetalone

IPA canonical pathways
Ingenuity® Pathway Analysis	z-score
	TNFα	Apabetalone 5 μM	Apabetalone 20 μM
TREM1 signaling	3.8	− 1.8	− 3.1
Acute phase response signaling	3.8	− 1.6	− 3.1
SAPK/JNK signaling	3.7	− 1.3	− 2.8
IL-6 signaling	3.7	− 0.8	− 2.2
Dendritic cell maturation	3.7	− 2.2	− 4.0
HGF signaling	3.6	− 0.5	− 2.1
Neuroinflammation signaling pathway	3.6	− 1.6	− 2.1
Renin-angiotensin signaling	3.5	0.4	− 2.1
HMGB1 signaling	3.4	− 1.2	− 2.2
NF-κB signaling	3.4	− 1.4	− 2.9

Positive activation z-scores reflect the predicted activation of a canonical pathway (significant when > ~ 2)

Negative activation z-scores reflect the predicted inactivation of a canonical pathway (significant when < ~− 2)