Table 5.

HUVEC Nanostring: IPA® diseases and biological functions identified TNFα-activated processes inhibited by apabetalone

Diseases and biological functions
Ingenuity® Pathway Analysis	z-score
	TNFα	Apabetalone 5 μM	Apabetalone 20 μM
Migration of cells	6.0	− 1.4	− 4.1
Cell movement	5.9	− 1.2	− 4.2
Migration of tumor cells	5.4	− 2.4	− 3.8
Cell movement of phagocytes	5.4	− 1.1	− 3.4
Activation of cells	5.3	− 2.2	− 3.4
Cell movement of tumor cells	5.3	− 1.7	− 3.5
Activation of blood cells	5.3	− 1.8	0
Homing of cells	5.2	− 1.0	− 3.5
Cell movement of myeloid cells	5.2	− 0.8	− 3.4
Activation of leukocytes	5.2	− 1.7	− 3.0
Chemotaxis	5.2	− 0.9	− 3.4
Cell movement of leukocytes	5.1	− 0.7	− 3.3
Leukocyte migration	5.1	− 0.8	− 3.2
Activation of phagocytes	4.9	− 1.9	− 3.1
Activation of myeloid cells	4.7	− 1.4	− 3.1
Activation of mononuclear leukocytes	4.5	− 0.8	− 2.6
Migration of phagocytes	4.4	− 1.2	− 2.7
Quantity of cells	4.4	− 1.3	− 2.0
Chemotaxis of myeloid cells	4.4	− 0.8	− 2.7
Attraction of cells	4.4	− 0.8	− 3.1
Recruitment of cells	4.4	− 1.0	− 2.9
Expression of RNA	4.4	− 1.7	− 3.4
Transcription	4.4	− 1.3	− 3.0
Inflammatory response	4.3	− 1.5	− 3.4

Positive activation z-scores reflect the predicted activation of a disease or function (significant when > ~ 2)

Negative activation z-scores reflect the predicted suppression of a disease or function (significant when < ~− 2)