Table 6.

THP-1 cytokine, chemokine, TLR signaling, and adhesion transcripts impacted by TNFα and apabetalone treatment

Function	Genes	TNFα
		Fold induction	% reduction
		Control	Apabetalone 5 μM	Apabetalone 20 μM
Cytokines	IL-1β	3.5	− 75	− 84
	TNFα	3.8	NS	− 54
Chemokines	CCR1	1.4	− 51	− 85
	CCR2	0.5	− 50	− 92
	MCP-1	3.7	− 77	− 91
TLR signaling	MYD88	2.6	− 39	− 71
	TLR4	0.7	NS	− 51
Adhesion molecules	CD44	1.8	− 26	− 39
	VLA-4	0.9	− 35	− 61