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. 2019 Jul 12;19:685. doi: 10.1186/s12885-019-5904-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The role of p65 phosphorylation in MMP7 and SREBP1 increased concomitantly. SREBP1 promotes the expression of MMP7 and activates phosphorylation of NF-κB protein p65. a, b the relationship between SREBP1 and MMP7 tested by western bolt. c, d the relationship between SREBP1 and P-65. e, f NF-κB inhibitor SN50 can inhibit the expression of MMP7. (HT29 SREBP1^oe that over-expressed SREBP1 in the HT29 cell line is represented by HT29+, SW620 SREBP1^kd that had stably knocked down SREBP1 in the SW620 cell line is represented by SW620-)