Table 3.

Brain regions with significantly (one tailed Z > 2.75, p < 0.005) greater mental stress-induced activation or deactivation in women (n = 53) relative to men (n = 112) with coronary artery disease as measured with [¹⁵O]H₂O positron emission tomography

Voxel number	Brain regions	Brodmann’s area	Talairach			Z score
			X	Y	Z
Greater stress activation in women than men
22	L cerebellum		− 26	− 40	− 18	5.26
86	L cerebellum		− 18	− 69	− 18	4.85
	L cerebellum		− 16	− 76	− 13	3.61
42	R parietal lobe, postcentral gyrus	40	51	− 32	50	4.75
26	R cerebellum		46	− 63	− 19	4.25
36	R cerebellum		10	− 72	− 10	4.25
11	R parietal lobe, postcentral gyrus	3	53	− 9	49	4.13
	R frontal lobe, precentral gyrus	6	48	− 7	54	2.82
96	L cerebellum		− 44	− 48	− 26	3.87
	L cerebellum		− 48	− 40	− 32	3.52
66	R posterior cingulate	31	8	− 43	39	3.74
	R parietal lobe, precuneus	7	4	− 51	38	3.54
12	L occipital lobe, fusiform gyrus	19	− 42	− 65	− 9	3.73
14	R frontal lobe, precentral gyrus	6	59	− 10	42	3.72
22	R cerebellum		24	− 50	− 23	3.56
19	R frontal lobe, superior gyrus	9	42	37	32	3.55
	R frontal lobe, middle gyrus	9	42	46	26	2.66
33	R parietal lobe, inferior lobule	40	48	− 58	48	3.53
68	R parietal lobe, superior lobule	7	30	− 59	53	3.51
	R parietal lobe, inferior lobule	40	38	− 52	53	3.38
19	R cerebellum		22	− 75	− 15	3.47
32	L temporal lobe, fusiform gyrus	37	− 50	− 61	− 17	3.44
12	R frontal lobe, precentral gyrus	44	59	10	13	3.28
Greater stress deactivation in women than men
23	L anterior cingulate	24	− 4	23	24	5.02
51	R frontal lobe, superior gyrus	6	14	22	51	5.00
95	R frontal lobe, inferior gyrus	47	24	22	− 20	4.67
	R frontal lobe, orbital gyrus	47	22	30	− 23	3.07
64	L frontal lobe, medial gyrus	6	− 14	29	36	4.63
	L frontal lobe, superior gyrus	8	− 10	32	47	3.50
86	R frontal lobe, inferior gyrus	47	44	27	− 8	4.53
	R frontal lobe, inferior gyrus	47	50	28	− 13	4.04
46	L frontal lobe, superior gyrus	6	− 6	14	55	4.46
	L frontal lobe, superior gyrus	6	0	11	58	3.25
28	L parietal lobe, supramarginal gyrus	40	− 63	− 43	27	4.39
	L temporal lobe, supramarginal gyrus	40	− 63	− 51	23	3.35
49	L frontal lobe, inferior gyrus		− 53	18	1	4.06
17	L parietal lobe, superior lobule	7	− 26	− 64	50	4.00
32	R temporal lobe, middle gyrus	21	69	− 45	− 8	3.99
37	L parietal lobe, precuneus	7	− 14	− 44	59	3.84
26	R frontal lobe, medial gyrus	9	22	38	23	3.84
34	L frontal lobe, medial gyrus	10	− 6	55	7	3.81
34	R temporal lobe, middle gyrus	21	61	− 3	− 17	3.74
11	R anterior cingulate	32	2	27	34	3.73
26	R frontal lobe, subcallosal gyrus	34	18	7	− 12	3.68
13	L frontal lobe, superior gyrus	8	0	28	49	3.67
36	R frontal lobe, medial gyrus	10	10	55	17	3.55
	R frontal lobe, medial gyrus	9	2	46	18	2.82
51	R frontal lobe, middle gyrus	11	42	42	− 19	3.54
	R frontal lobe, middle gyrus	11	38	52	− 14	3.42
31	L parietal lobe, postcentral gyrus	5	− 30	− 44	58	3.53
14	L frontal lobe, middle gyrus	6	− 38	12	46	3.53
14	L frontal lobe, inferior gyrus	45	− 59	18	6	3.50
18	L frontal lobe, precentral gyrus	4	− 44	− 18	33	3.46
13	L frontal lobe, superior gyrus	8	− 22	16	48	3.44
24	R frontal lobe, middle gyrus	8	30	16	41	3.33
29	R parietal lobe, supramarginal gyrus	40	57	− 47	31	3.30
	R parietal lobe, inferior lobule	40	51	− 51	38	3.15
11	L parietal lobe, precuneus	7	− 10	− 40	47	3.27
12	R frontal lobe, medial gyrus	10	2	54	− 9	3.15
15	L parietal lobe, postcentral gyrus	3	− 28	− 23	46	3.13
11	L frontal lobe, inferior gyrus		− 40	43	3	2.99
17	L frontal lobe, middle gyrus	11	− 38	50	− 14	2.95
13	R parahippocampal gyrus	30	8	− 39	7	2.77