Fig. 3.

YAP conferred BEL/FU cells with chemoresistance in vivo. Balb/c nude mice with subcutaneous xenograft tumours were treated with PBS, 5-Fu (20 mg/kg), DOX (1 mg/kg), verteporfin (10 mg/kg) or a combination of verteporfin and 5-Fu or DOX intraperitoneally every 3 days. a Tumour appearance. b Tumour volumes. c Tumour weights. d The expression of p-mTOR, p-S6 and 8-OHdG was examined by IHC analysis of the tumour tissues (scale bar: 50 µm/25 µm). e, f Apoptosis was analysed in tumour tissues by terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay (scale bar: 50 µm). The average number of apoptotic cells from 10 random fields of magnification (200×). Data are presented as the mean ± SD. **p < 0.01