Table 1.
Characteristics of the study sample examining estimated glomerular filtration rate (eGFR)
| HUNT 2 (1995–1997) | No dementia | Total Dementia | Combined AD/VaD/Mixed AD/VaD | AD | VaD | Mixed AD/VaD | Other Dementia | P value A |
|---|---|---|---|---|---|---|---|---|
| Total study population, n | 47,840 | 668 | 528 | 348 | 112 | 68 | 140 | |
| eGFR, mean (SD) | 78.99 (16.15) | 63.89 (12.39) | 63.13 (12.40) | 62.79 (12.12) | 64.97 (14.39) | 61.88 (9.84) | 66.74 (11.91) | .00 |
| 4 stages eGFR, n (%) | .00 | |||||||
| > 90 | 11,708 (24.5) | 16 (2.4) | 12 (2.3) | 8 (2.3) | 4 (3.6) | 0 | 4 (2.9) | |
| 60.0–89.9 | 30,347 (63.4) | 397 (59.4) | 306 (58.0) | 196 (56.3) | 68 (60.7) | 42 (61.8) | 91 (65.0) | |
| 30.0–59.9 | 5697 (11.9) | 251 (37.6) | 207 (39.2) | 143 (41.1) | 38 (33.9) | 26 (38.2) | 44 (31.4) | |
| < 30 | 88 (.2) | 4 (.6) | 3 (.6) | 1 (.3) | 2 (1.8) | 0 | 1 (.7) | |
| Diabetes Mellitus, n (%) | 1307 (2.7) | 34 (5.1) | 31 (5.9) | 18 (5.2) | 8 (7.1) | 5 (7.4) | 3 (2.1) | .00 |
| Anti-hypertensive tablets, ever, n (%) | 6476 (13.5) | 211 (31.6) | 173 (32.8) | 102 (29.3) | 48 (42.9) | 23 (33.8) | 38 (27.1) | .00 |
| Sex, Female, n (%) | 25,806 (53.9) | 410 (61.4) | 341 (64.6) | 238 (68.4) | 58 (51.8) | 45 (66.2) | 69 (49.3) | .00 |
| Age at HUNT 2 (1995–1997), mean (SD) | 49.24 (16.55) | 70.58 (7.54) | 71.26 (6.99) | 71.62 (6.80) | 69.82 (8.19) | 71.84 (5.38) | 68.02 (8.93) | .00 |
| Time to debut, years, mean (SD) | 7.15 (3.63) | 7.15 (3.65) | 7.20 (3.76) | 7.41 (3.53) | 6.45 (3.16) | 7.16 (3.57) | ||
| Education, n (%) | .00 | |||||||
| Primary | 17,234 (36.0) | 458 (68.6) | 367 (69.5) | 240 (69.0) | 77 (68.8) | 50 (73.5) | 91 (65.0) | |
| Completed secondary | 26,830 (56.1) | 195 (29.2) | 151 (28.6) | 104 (29.9) | 30 (26.8) | 17 (25.0) | 44 (31.4) | |
| Completed upper secondary | 3776 (7.9) | 15 (2.2) | 10 (1.9) | 4 (1.1) | 5 (4.5) | 1 (1.5) | 5 (3.6) | |
| Cholesterol (mmol/L), mean (SD) | 5.87 (1.25) | 6.65 (1.24) | 6.70 (1.24) | 6.72 (1.23) | 6.65 (1.5) | 6.64 (1.29) | 6.46 (1.21) | .00 |
| Non-fasting blood glucose (mmol/L), mean (SD) | 5.42 (1.46) | 5.88 (1.78) | 5.91 (1.79) | 5.89 (1.85) | 6.03 (1.84) | 5.77 (1.37) | 5.78 (1.74) | .00 |
| Serum iron (), mean (SD) | 16.51 (6.31) | 16.08 (5.74) | 15.99 (5.79) | 16.07 (5.89) | 15.55 (5.71) | 16.28 (5.55) | 16.45 (5.58) | .06 |
| Body Mass Index (kg/m2) mean (SD) | 26.32 (4.07) | 27.03 (4.11) | 26.96 (4.04) | 26.76 (4.03) | 27.62 (4.39) | 26.91 (3.34) | 27.28 (4.36) | .00 |
| Pulse (beats/min), mean (SD) | 72.96 (12.56) | 73.63 (13.87) | 73.70 (13.71) | 73.77 (14.44) | 72.41 (11.77) | 75.50 (12.72) | 73.36 (14.53) | .21 |
| Systolic BP (mmHg), mean (SD) | 136.86 (21.23) | 153.27 (23.23) | 153.94 (23.52) | 153.96 (23.63) | 153.63 (22.17) | 154.34 (25.34) | 150.72 (21.99) | .00 |
| Diastolic BP (mmHg), mean (SD) | 80.02 (12.01) | 84.68 (12.56) | 84.73 (12.56) | 83.97 (12.50) | 86.47 (12.27) | 85.69 (13.13) | 84.50 (12.62) | .00 |
| Myocardial Infarction, n (%) | 1444 (3.0) | 40 (6.0) | 32 (6.1) | 18 (5.2) | 10 (8.9) | 4 (5.9) | 8 (5.7) | .00 |
| Angina Pectoris, n (%) | 2178 (4.6) | 90 (13.5) | 71 (13.4) | 46 (13.2) | 15 (13.4) | 10 (14.7) | 19 (13.6) | .00 |
| Stroke, n (%) | 809 (1.7) | 25 (3.7) | 21 (4.0) | 7 (2.0) | 12 (10.7) | 2 (2.9) | 4 (2.9) | .00 |
| Daily Smoker, n (%) | 13,425 (28.1) | 110 (16.5) | 80 (15.2) | 44 (12.6) | 25 (22.3) | 11 (16.2) | 30 (21.4) | .00 |
| Subjective health status | .00 | |||||||
| Poor, n (%) | 752 (1.6) | 13 (1.9) | 12 (2.3) | 7 (2.0) | 5 (4.5) | 0 | 1 (.7) | |
| Not so good, n (%) | 11,646 (24.3) | 303 (45.4) | 239 (45.3) | 149 (42.8) | 55 (49.1) | 35 (51.5) | 64 (45.7) | |
| Good, n (%) | 27,659 (57.8) | 323 (48.4) | 260 (49.2) | 181 (52.0) | 47 (42.0) | 32 (47.1) | 63 (45.0) | |
| Very good, n (%) | 7783 (16.3) | 29 (4.3) | 17 (3.2) | 11 (3.2) | 5 (4.5) | 1 (1.5) | 12 (8.6) |
AP-values are derived from t tests for continuous variables and x2 tests for the binary variables comparing means between total dementia and no dementia