Table 2.
Cox proportional regression models on the association of glomerular filtration rate (eGFR) and dementia. Hazard ratios are presented with 95% confidence intervals
| Total Dementia | NCA | Combined AD, VaD, Mixed AD/VaD | NC | AD | NC | VaD | NC | Mixed AD/VaD | NC | Other Dementia | NC | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| eGFR | 668 | 528 | 348 | 112 | 68 | 140 | |||||||
| Model 1c | > 90 | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| 69.0–89.9 | 9.96 (6.04–16.42) | 10.52 (5.76–18.26) | 9.88 (4.87–20.03) | 6.86 (2.50–18.81) | not sig | 9.17 (3.37–24.96) | |||||||
| 30.0–59.9 | 41.73 (25.17–69.19) | 46.10 (25.75–82.51) | 48.22 (23.65–98.31) | 26.10 (9.31–73.17) | not sig | 29.77 (10.69–82.88) | |||||||
| < 30 | 62.85 (21.00–188.06) | 63.22 (17.83–224.14) | 32.70 (4.09–261.59) | 131.97 (24.14–721.62) | not sig | 65.94 (7.36–590.56) | |||||||
| Model 2d | > 90 | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| 69.0–89.9 | 1.38 (.82–2.34) | 1.24 (.68–2.26) | 1.09 (.52–2.29) | 1.08 (.37–3.16) | not sig | 2.03 (.71–5.80) | |||||||
| 30.0–59.9 | 1.24 (.71–2.16) | 1.09 (.58–2.07) | .98 (.45–2.15) | .97 (.30–3.13) | not sig | 1.87 (.60–5.82) | |||||||
| < 30 | 1.68 (.55–5.17) | 1.37 (.38–5.02) | .62 (.08–5.10) | 4.16 (.69–24.99) | not sig | 3.50 (.37–33.22) | |||||||
| Model 3e | > 90 | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| 69.0–89.9 | 1.35 (.80–2.28) | 1.20 (.65–2.20) | 1.08 (.51–2.28) | .97 (.33–2.83) | not sig | 2.00 (.70–5.74) | |||||||
| 30.0–59.9 | 1.20 (.68–2.10) | 1.05 (.55–2.00) | .98 (.44–2.16) | .81 (.25–2.63) | not sig | 1.82 (.58–5.71) | |||||||
| < 30 | 1.64 (.53–5.05) | 1.34 (.37–4.92) | .64 (.08–5.33) | 3.10 (.51–18.79) | not sig | 3.43 (.36–32.72) | |||||||
| Model 4f | > 90 | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| 69.0–89.9 | 1.34 (.79–2.26) | 1.18 (.64–2.16) | 1.06 (.50–2.22) | .97 (.33–2.83) | not sig | 2.04 (.71–5.82) | |||||||
| 30.0–59.9 | 1.17 (.67–2.06) | 1.02 (.54–1.94) | .96 (.43–2.12) | .75 (.23–2.44) | not sig | 1.84 (.59–5.81) | |||||||
| < 30 | 1.57 (.51–4.85) | 1.24 (.34–4.58) | .65 (.08–5.35) | 2.29 (.37–14.08) | not sig | 3.69 (.38–35.55) | |||||||
| eGFR*Age | |||||||||||||
| > 90 | Ref | Ref | Ref | Ref | Ref | Ref | |||||||
| 69.0–89.9 | .95 (.91–.99) | .97 (.92–1.02) | .96 (.90–1.02) | .99 (.90–1.10) | not sig | .90 (.82–.99) | |||||||
| 30.0–59.9 | .90 (.86–.94) | .91 (.86–.96) | .90 (.84–.96) | .96 (.6–1.06) | not sig | .85 (.77–.94) | |||||||
| < 30 | .88 (.79–.98) | .88 (.78–.98) | .88 (.72–1.07) | .91 (.77–1.06) | not sig | .92 (.69–1.22) | |||||||
| eGFR*Sex | |||||||||||||
| > 90 | Ref | Ref | Ref | Ref | Ref | Ref | |||||||
| 69.0–89.9 | 1.98 (.72–5.44) | 3.25 (1.01–10.49) | 2.15 (.52–8.85) | 9.98 (.98–101.33) | not sig | not sig | |||||||
| 30.0–59.9 | 1.67 (.59–4.69) | 2.80 (.85–9.30) | 1.34 (.31–5.80) | 17.33 (1.63–183.87) | not sig | not sig | |||||||
| < 30 | 2.58 (.29–23.32) | 9.41 (.65–135.41) | .00 (.00–.00) | .00 (.00–.00) | not sig | not sig | |||||||
A Number of dementia cases
B Age when examined in HUNT 2
C Model 1: Categorized estimated Glomerular filtration rate (eGFR)
D Model 2: eGFR, age, sex, education
E Model 3: eGFR, age, sex, education, glomerular filtration rate, cholesterol, non-fasting blood glucose, serum iron, body mass index, pulse
F Model 4: eGFR, age, sex, education, glomerular filtration rate, cholesterol, non-fasting blood glucose, serum iron, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status